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KMID : 1007520100190041123
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Food Science and Biotechnology
2010 Volume.19 No. 4 p.1123 ~ p.1127
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Anti-obesity Activity of Methanol Extract from Hot Pepper (Capsicum annuum L.) Seeds in 3T3-L1 Adipocyte
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Jeon Geon-uk
Choi Young-Min
Lee Seon-Mi
Kim Young-Hwa
Jeong Heon-Sang
Lee Jun-Soo
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Abstract
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Anti-adipogenesis activity of methanol extract from hot pepper (Capsicum annuum L.) seeds (PSE) was evaluated. Exposure to PSE (25-200 μg/mL) for a 72 hr incubation period did not alter cell viability compared to the control. The adipocyte treated with PSE at the concentration of 200, 100, and 50 μg/mL showed decreased color intensity as compared to the control suggesting decreased lipid accumulation in the adipocyte. Moreover, the glycerol-3-phosphate dehydrogenase activity was significantly reduced. The expression of C/EBPβ, C/EBPα, and PPARγ, important adipogenic transcription factors, was significantly reduced when PSE was added to cells from day 0 to 6 as compared with the control group. The results suggest that PSE has significant health-promoting effects, having excellent anti-obesity activities.
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KEYWORD
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anti-obesity, hot pepper seed, adipocyte, lipid accumulation, 3T3-L1
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